|
KMID : 1044720120020020057
|
|
Journal of Lifestyle Medicine
2012 Volume.2 No. 2 p.57 ~ p.65
|
|
|
The Arcuate Nucleus and the Ventromedial Nucleus of the Hypothalamus; Sites for Energy Homeostasis
|
|
Lee Ji-Won
Kim Min
Kim Ki-Woo
|
|
|
Abstract
|
|
|
|
The hypothalamus regulates food intake, body weight, and glucose homeostasis. Among many hypothalamic nuclei, the arcuate nucleus of the hypothalamus (ARC) is known as a primary site where leptin and insulin act in the brain to modulate whole body metabolism. In addition to the ARC, the ventromedial hypothalamic nucleus of the hypothalamus (VMH) is also a famous brain site for regulation of body weight and food consumption. We recently have witnessed significant advances in genetically modified animal model systems that allow us to address the specific questions about hypothalamic circuits that control energy and glucose homeostasis. In this mini-review, we describe the functional roles of the ARC in the regulation of body weight homeostasis. In particular, we focus on two distict neuronal populations, POMC and NPY/AgRP neurons, in the nucleus. Further, we discuss the recent advance in understanding metabolic control taking place in the VMH.
|
|
|
KEYWORD
|
|
|
Arcuate nucleus of the hypothalamus, Energy homeostasis, Glucose homeostasis, Obesity, Ventral medial hypothalamic nucleus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|